ABSTRACT Objective: To determine the efficacy of weight reduction program in improving the cardiopulmonary system in prehypertensive obese males. Methods of Evaluation: (Measurement of body mass index, blood pressure, lipid profile, forced vital capacity and application of resting electrocardiogram) been used. Subjects: Fifty prehypertensive obese males aged from 35 to 45 years received weight reduction program in form of aerobic exercises for a duration of 30-45 minutes and diet regimen program, every other day for 6 months as a total period of treatment. Results: The results suggest that the program of weight reduction is effective in decreasing the blood pressure, lipid profile, forced vital capacity, ST segment and T wave readings of ECG diameters in prehypertensive obese males. Conclusion: It was concluded that the study showed the efficacy of weight reduction program in avoidance of cardiopulmonary diseases and improvement of cardiopulmonary state in prehypertensive obese males. Whenever there’s high value of body mass index change reduction, witch gives the expected improvement of cardiopulmonary system. Key words: cardiopulmonary system, weight reduction, prehypertension, obesity).